CYM 5442
货号：
16925-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 16925-1mg |
| 描述 | Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 is important for vascular development and lymphocyte maturation, migration, and trafficking.1 CYM 5442 is a full agonist for S1P1 internalization, phosphorylation, and ubiquitination (EC50 = 1.35 nM).2 It is ineffective at S1P2, S1P3, S1P4, and S1P5 at concentrations up to 10 µM.2 CYM 5442 has been found to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 with an EC50 value of 46 nM.2 At 50 nM, CYM 5442 can induce S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rosen, H.,Stevens, R.C.,Hanson, M., et al. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence. Annual Reviews of Biochemistry 82, 637-662 (2013).
2.Gonzalez-Cabrera, P.J.,Jo, E.,Sanna, M.G., et al. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Molecular Pharmacology 74(5), 1308-1318 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 409.5 |
| 分子式 | C23H27N3O4 |
| CAS号 | 1094042-01-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
