GSK690693
货号：
16891-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 16891-1mg |
| 描述 | GSK690693 is an ATP-competitive, pan-Akt kinase inhibitor with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively.1 It also inhibits other members of the AGC kinase family, including AMPK, DAPK3, PAKs, PKA, PKC, PKG, and PrkX (IC50 values range from 2-81 nM).1 By preventing the phosphorylation of downstream Akt substrates, GSK690693 has been shown to inhibit proliferation and to induce apoptosis in various human tumor cells in vitro and in xenografts in immunocompromised mice.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rhodes, N.,Heerding, D.A.,Duckett, D.R., et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Research 68(7), 2366-2374 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 425.5 |
| 分子式 | C21H27N7O3 |
| CAS号 | 937174-76-0 |
| 稳定性 | ≥ 2 years |
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