| 货号 | 16867-5mg |
| 描述 | m-3M3FBS is an activator of phospholipase C (PLC) that stimulates superoxide generation, increase in cytoplasmic calcium, and inositol phosphate formation in human neutrophils when used at a concentration of 15-50 µM.1 It stimulates cytoplasmic calcium increases in several cell lines and, at 25 µM in vitro, promotes the hydrolysis of phosphatidylinositol bisphosphate by all PLC isoforms.1m-3M3FBS is used to study PLC signaling in cells and animals, often in conjunction with the PLC inhibitor U-73122 (Item No. 70740).2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bae, Y.S.,Lee, T.G.,Park, J.C., et al. Identification of a compound that directly stimulates phospholipase C activity. Molecular Pharmacology 63(5), 1043-1050 (2003). 2.Kim, S.D.,Kim, H.J.,Shim, J.W., et al. Phospholipase C activator m-3M3FBS protects against morbidity and mortality associated with sepsis. Journal of Immunology 189(4), 2000-2005 (2012). 3.Semple-Rowland, S.,Madorsky, I.,Bolch, S., et al. Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors. PLoS One 8(12), 1-7 (2013). 4.Szebenyi, S.A.,Ogura, T.,Sathyanesan, A., et al. Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons. Front.Cell.Neurosci. 8, 1-14 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 343.4 |
| 分子式 | C16H16F3NO2S |
| CAS号 | 200933-14-8 |
| 稳定性 | ≥ 2 years |
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