Eg5-I
货号：
16668-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 16668-1mg |
| 描述 | The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis.1 Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively).2 It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM).2 It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Item No. 15044), which also acts by inhibiting Eg5.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Good, J.A.D.,Skoufias, D.A. and Kozielski, F. Elucidating the functionality of kinesins: An overview of small molecule inhibitors. Seminars in Cell & Developmental Biology 22(9), 935-945 (2011).
2.Rodriguez, D.,Ramesh, C.,Henson, L.H., et al. Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity. Bioorganic & Medicinal Chemistry 19(18), 5446-5453 (2011).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.5 |
| 分子式 | C23H25NO2S |
| CAS号 | 1338701-15-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
