| 货号 | 16548-5mg |
| 描述 | D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM).1,2,3 It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells.4,5 D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein.6 By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.7 |
| 别名 | NSC 226836; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coore, H.G. and Randle, P.J. Inhibition of glucose phosphorylation by mannoheptulose. Biochemistry Journal 91(1), 56-59 (1964). 2.Ashcroft, S.J.H. and Randle, P.J. Enzymes of glucose metabolism in normal mouse pancreatic islets. Biochemistry Journal 119(1), 5-15 (1970). 3.Dai, N.,Schaffer, A.,Petreikov, M., et al. Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence. Plant Cell 11(7), 1253-1266 (1999). 4.Ashcroft, S.J.H.,Weerasinghe, L.C. and Randle, P.J. Interrelationship of islet metabolism, adenosine triphosphate content and insulin release. Biochemistry Journal 132(2), 223-231 (1973). 5.Johnson, D.,Shepherd, R.M.,Gill, D., et al. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator. Diabetes 56(6), 1694-1702 (2007). 6.Li, M.V.,Chen, W.,Harmancey, R.N., et al. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochemical and Biophysical Research Communications 395(3), 395-400 (2010). 7.McKnight, L.L.,Flickinger, E.A.,France, J., et al. Mannoheptulose has differential effects on fasting and postprandial energy expenditure and respiratory quotient in adult Beagle dogs fed diets of different macronutrient contents. J.Nutr.Sci. 3(17), 1-7 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 210.2 |
| 分子式 | C7H14O7 |
| CAS号 | 3615-44-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |