| 货号 | 16455-1mg |
| 描述 | Malonyl coenzyme A is a coenzyme A (CoA; Item No. 16147) derivative that is used in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane.1,2 Malonyl-CoA is formed by acetyl-CoA carboxylase-mediated carboxylation of acetyl-CoA (Item No. 16160).1 Fatty acid synthase catalyzes the NADPH-dependent condensation of malonyl-CoA and acetyl-CoA to produce palmitate. Proliferating human cancer cells upregulate this fatty acid synthesis pathway as a strategy for survival. High levels of malonyl-CoA, achieved through fatty acid synthase inhibition, have been proposed to contribute to cancer cell apoptosis.3 Manlonyl-CoA is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides.2,4 |
| 别名 | Malonyl-CoA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hiltunen, J.K.,Autio, K.J.,Schonauer, M.S., et al. Mitochondrial fatty acid synthesis and respiration. Biochim.Biophys.Acta. 1797(6-7), 1195-1202 (2010). 2.Summers, R.G.,Ali, A.,Shen, B., et al. Malonyl-coenzyme A:Acyl carrier protein acyltransferase of Streptomyces glaucescens: A possible link between fatty acid and polyketide biosynthesis. Biochem. 34(29), 9389-9402 (1995). 3.Pizer, E.S.,Thupari, J.,Han, W.F., et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Research 60, 213-218 (2000). 4.Zhan, J. Biosynthesis of bacterial aromatic polyketides. Current Topics in Medicinal Chemistry 9(17), 1598-1610 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 860.5 |
| 分子式 | C24H38N7O19P3S • XLi |
| CAS号 | 108347-84-8 |
| 稳定性 | ≥ 2 years |
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