| 货号 | 15475-10mg |
| 描述 | Idebenone is a benzoquinone analog of coenzyme Q10 (Item No. 11506), a natural quinone that serves as a cofactor in the electron transport chain in mitochondria.1,2 Like coenzyme Q10, idebenone is a potent lipid antioxidant that prevents the generation of free radicals.1,3 In particular, idebenone targets mitochondria, preserves mitochondrial function, and confers cytoprotection.4,5,6 In this way, idebenone has neuroprotective effects and has applications in Friedreich ataxia.7,8 |
| 别名 | CV-2619;Mnesis; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Saini, R. Coenzyme Q10: The essential nutrient. J.Pharm.Bioallied Sci. 3(3), 466-467 (2011). 2.Crane, F.L. Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition 20(6), 591-598 (2001). 3.Suno, M. and Nagaoka, A. Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619). Japanese Journal of Pharmacology 35(2), 196-198 (1984). 4.Arce, P.M.,Goldschmidt, R.,Khdour, O.M., et al. Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection. Bioorganic & Medicinal Chemistry 20(17), 5188-5201 (2012). 5.Erb, M.,Hoffman-Enger, B.,Deppe, H., et al. Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex I. PLoS One 7(4), e36153 (2012). 6.Heitz, F.D.,Erb, M.,Anklin, C., et al. Idebenone protects against retinal damage and loss of vision in a mouse model of Leber’s hereditary optic neuropathy. PLoS One 7(9), e45182 (2012). 7.Liu, J. and Wang, L.N. Mitochondrial enhancement for neurodegenerative movement disorders: A systematic review of trials involving creatine, coenzyme q10, idebenone and mitoquinone. CNS Drugs 28(1), 63-68 (2014). 8.Tsou, A.Y.,Friendman, L.A.,Wilson, R.B., et al. Pharmacotherapy for Friedreich ataxia. CNS Drugs 23(3), 213-223 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 338.4 |
| 分子式 | C19H30O5 |
| CAS号 | 58186-27-9 |
| 稳定性 | ≥ 2 years |
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