FG-4592
货号：
15294-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 15294-5mg |
| 描述 | The hypoxia-inducible factor (HIF) pathway alters gene expression in response to low oxygen tension. Under normoxic conditions, HIF-specific prolyl hydroxylases (HIF-PHs) initiate the degradation of oxygen-sensitive HIF isoforms. As 2-oxoglutarate (2-OG) is a required co-factor for HIF-PH activity, analogs of 2-OG may inhibit HIF-PH and prevent HIF turnover.1 FG-4592 is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs. While little has been published regarding the actions of this compound, similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.2 |
| 别名 | ASP1517;Roxadustat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bruegge, K.,Jelkmann, W. and Metzen, E. Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-α hydroxylases. Current Medicinal Chemistry 14(17), 1853-1862 (2007).
2.Hsieh, M.M.,Linde, N.S.,Wynter, A., et al. HIF-prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaque. Blood 110(6), 2140-2147 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.4 |
| 分子式 | C19H16N2O5 |
| CAS号 | 808118-40-3 |
| 稳定性 | ≥ 2 years |
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