| 货号 | 15036-1mg |
| 描述 | JSH-23 is an inhibitor of NF-κB, blocking its translocation into the nucleus (IC50 = 7.1 µM).1 It does not affect degradation of the inhibitor of NF-κB, IκB.1 JSH-23 interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with lipopolysaccharide.1 It has also been used to investigate the roles of NF-κB in cancer, inflammation, and neurogenesis.2,3,4 |
| 别名 | NF-κB Activation Inhibitor II; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shin, H.M.,Kim, M.H.,Kim, B.H., et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-κB without affecting IκB degradation. FEBS Letters 571(1-3), 50-54 (2004). 2.Ahmed, K.M.,Zhang, H. and Park, C.C. NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells. Cancer Research 73(12), 3737-3748 (2013). 3.Kumar, A.,Negi, G. and Sharma, S.S. JSH-23 targets nuclear factor-kappa B and reverses various deficits in experimental diabetic neuropathy: Effect on neuroinflammation and antioxidant defence. Diabetes Obes.Metab. 13(8), 750-758 (2011). 4.Koo, J.W.,Russo, S.J.,Ferguson, D., et al. Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proceedings of the National Academy of Sciences of the United States of America 107(6), 2669-2674 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 240.3 |
| 分子式 | C16H20N2 |
| CAS号 | 749886-87-1 |
| 稳定性 | ≥ 2 years |
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