| 货号 | 14998-10mg |
| 描述 | Paroxetine is a phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the human serotonin transporter with a Ki value of 0.72 nM.1 It less effectively blocks the human norepinephrine and dopamine transporters (Ki = 440 and 1,900 nM, respectively).1 Paroxetine also inhibits, at concentrations in excess of 1 µM, nitric oxide synthase activity in the cytosol of hamster brain.2 Selective serotonin uptake inhibitors, including paroxetine, are used in cases of depression and anxiety disorder.3,4 |
| 别名 | BRL 29060A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mattson, R.J.,Catt, J.D.,Denhart, D.J., et al. Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. Journal of Medicinal Chemistry 48(19), 6023-6034 (2005). 2.Finkel, M.S.,Laghrissi-Thode, F.,Pollock, B.G., et al. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacology Bulletin 32, 653-658 (1996). 3.Baldwin, D.,Woods, R.,Lawson, R., et al. Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis. BMJ 342, d1199 (2011). 4.Ackermann, R.T. and Williams, J.W., Jr. Rational treatment choices for non-major depressions in primary care. J.Gen.Intern.Med. 17(4), 293-301 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.3 |
| 分子式 | C19H20FNO3 • HCl |
| CAS号 | 78246-49-8 |
| 稳定性 | ≥ 2 years |
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