| 货号 | 14956-100mg |
| 描述 | Imiquimod is an imidazoquinoline compound that activates toll-like receptor 7 (EC50 = 2.1 µM) on immune cells, inducing the production of IFN-α, IL-12, and other mediators.1,2,3 It also up-regulates the opioid growth factor (OGF) receptor on a variety of cancer cell types, enabling an OGF-mediated block of cell proliferation (IC50 = 2 µM).4 These actions make imiquimod efficacious as an anti-viral and anti-tumor compound when applied topically.4,5 |
| 别名 | Aldara;Beselna;R-837;TMX 101;Zyclara; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hemmi, H.,Kaisho, T.,Takeuchi, O., et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunology 3(2), 196-200 (2002). 2.Shukla, N.M.,Mallardi, S.S.,Mutz, C.A., et al. Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. Journal of Medicinal Chemistry 53(11), 4450-4465 (2010). 3.Miller, R.L.,Gerster, J.F.,Owens, M.L., et al. Imiquimod applied topically: A novel immune response modifier and new class of drug. International Journal of Immunopharmacology 21(1), 1-14 (1999). 4.Zagon, I.S.,Donahue, R.N.,Rogosnitzky, M., et al. Imiquimod upregulates the opioid growth factor receptor to inhibit cell proliferation independent of immune function. Exp.Biol.Med.(Maywood) 233(8), 968-979 (2008). 5.Sauder, D.N. Imiquimod: Modes of action. British Journal of Dermatology 149(66), 5-8 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 240.3 |
| 分子式 | C14H16N4 |
| CAS号 | 99011-02-6 |
| 稳定性 | ≥ 2 years |
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