| 货号 | 14951-50mg |
| 描述 | Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis.1 Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures.2,3 At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells.4,5 Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.1,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vetri, V.,Ossato, G.,Militello, V., et al. Fluctuation methods to study protein aggregation in live cells: Concanavalin A oligomers formation. Biophysical Journal 100(3), 774-783 (2011). 2.Schiefer, H.G.,Krauss, H.,Brunner, H., et al. Ultrastructural visualization of surface carbohydrate structures on mycoplasma membranes by concanavalin A. Journal of Bacteriology 124(3), 1598-1600 (1975). 3.Robinson, J.E.,Holton, D.,Liu, J., et al. A novel enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to HIV-1 envelope glycoproteins based on immobilization of viral glycoproteins in microtiter wells coated with concanavalin A. Journal of Immunological Methods 132, 63-71 (1990). 4.Wang, H.X.,Liu, M.,Weng, S.Y., et al. Immune mechanisms of concanavalin A model of autoimmune hepatitis. World Journal of Gastroenterology 18(2), 119-125 (2012). 5.Dwyer, J.M. and Johnson, C. The use of concanavalin A to study the immunoregulation of human T cells. Clinical and Experimental Immunology 46(2), 237-249 (1981). 6.Liu, B.,Min, M.W. and Bao, J.K. Induction of apoptosis by concanavalin A and its molecular mechanisms in cancer cells. Autophagy 5(3), 432-433 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| CAS号 | 11028-71-0 |
| 稳定性 | ≥ 2 years |
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