| 货号 | 14915-50mg |
| 描述 | Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine.1 It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine.2,3 Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling.4,5 This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.1,6 |
| 别名 | Matrine 1-oxide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ling, Q.,Xu, X.,Wei, X., et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J.Exp.Clin.Cancer Res. 30, 66 (2011). 2.Cui, X.,Wang, Y.,Kokudo, N., et al. Traditional Chinese medicine and related active compounds against hepatitis B virus infection. Biosci.Trends 4(2), 39-47 (2010). 3.Ma, Z.J.,Li, Q.,Wang, J.B., et al. Combining oxymatrine or matrine with lamivudine increased its antireplication effect against the hepatitis B virus in vitro. Evidence-Based Complementary and alternative Medicine 2013, 186573 (2013). 4.Chai, N.L.,Fu, Q.,Shi, H., et al. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World Journal of Gastroenterology 18(31), 4199-4206 (2012). 5.Wu, X.L.,Zeng, W.Z.,Jiang, M.D., et al. Effect of oxymatrine on the TGβSmad signaling pathway in rats with CCl4-induced hepatic fibrosis. World Journal of Gastroenterology 14(13), 2100-2105 (2008). 6.Guzman, J.R.,Koo, J.S.,Goldsmith, J.R., et al. Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation. Sci.Rep. 3, 1629 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.4 |
| 分子式 | C15H24N2O2 |
| CAS号 | 16837-52-8 |
| 稳定性 | ≥ 2 years |
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