AG-1024
货号：
14833-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 14833-1mg |
| 描述 | The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) initiates a cascade of reactions that promote cell growth and transformation by activating the PI3K/Akt signaling pathway, inhibiting apoptotic pathways, and mediating mitogenic actions. Overexpression of IGF-1R confers tumorigenic potential to cells as well as protection from apoptosis. AG-1024 is a selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively.1 At 10 nM, AG-1024 can inhibit proliferation and induce apoptosis in human breast cancer MCF-7 cells, and it inhibits autocrine growth of human prostate cancer DU145 cells with an IC50 value of 2.5 μM.2,3 |
| 别名 | AGS 200;Tyrphostin AG-1024; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Párrizas, M.,Gazit, A.,Levitzki, A., et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology 138(4), 1427-1433 (1997).
2.Wen, B.,Deutsch, E.,Marangoni, E., et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. British Journal of Cancer 85(12), 2017-2021 (2001).
3.Kisielewska, J.,Ligeza, J. and Klein, A. The effect of tyrosine kinase inhibitors, tyrphostins: AG1024 and SU1498, on autocrine growth prostate cancer cells (DU145). Folia Histochem.Cytobiol. 46(2), 185-191 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 305.2 |
| 分子式 | C14H13BrN2O |
| CAS号 | 65678-07-1 |
| 稳定性 | ≥ 2 years |
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