| 货号 | 14806-5mg |
| 描述 | R-848 is an immune response modifier that mimics the pathogen-associated molecular patterns that activate immune cells through Toll-like receptor 7 (TLR7) and TLR8. It demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections. 1,2,3 At 1 μg/ml, R-848 mimics CD40-induced B cell activation and can be used to induce the production of IFN-γ and various other cytokines.4,5 |
| 别名 | Resiquimod;S 28463; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bernstein, D.I.,Harrison, C.J.,Tomai, M.A., et al. Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment. Journal of Infectious Diseases 183(6), 844-849 (2001). 2.Nian, H.,Geng, W.Q.,Cui, H.L., et al. R-848 triggers the expression of TLR7/8 and suppresses HIV replication in monocytes. BMC Infect.Dis. 12, 5 (2012). 3.Hattermann, K.,Picard, S.,Borgeat, M., et al. The toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. The FASEB Journal 21(7), 1575-1585 (2007). 4.Bishop, G.A.,Hsing, Y.,Hostager, B.S., et al. Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. Journal of Immunology 165(10), 5552-5557 (2000). 5.Caron, G.,Duluc, D.,Frémaux, I., et al. Direct stimulation of human T cells via TLR5 and TLR7/8: Flagellin and R-848 up-regulate proliferation and IFN-γ production by memory CD4+ T cells. Journal of Immunology 175(3), 1551-1557 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.4 |
| 分子式 | C17H22N4O2 |
| CAS号 | 144875-48-9 |
| 稳定性 | ≥ 2 years |
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