| 货号 | 14640-5mg |
| 描述 | Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 μM, respectively.1 A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.2,3,4 |
| 别名 | AF 1890;DICA;Diclondazolic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Floridi, A.,Paggi, M.G.,DArti, S., et al. Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Cancer Research 41(11), 4661-4666 (1981). 2.Brawer, M.K. Lonidamine: Basic science and rationale for treatment of prostatic proliferative disorders. Rev.Urol. 7 (Suppl.7), 21-26 (2005). 3.Marrache, S. and Dhar, S. Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. Proceedings of the National Academy of Sciences of the United States of America 109(40), 16288-16293 (2012). 4.Miccoli, L.,Poirson-Bichat, F.,Sureau, F., et al. Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. Journal of the National Cancer Institute 90(18), 1400-1406 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 321.2 |
| 分子式 | C15H10ClN2O2 |
| CAS号 | 50264-69-2 |
| 稳定性 | ≥ 2 years |
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