Temozolomide
货号：
14163-10mg 基本售价：
546.0 元 规格：
10 mg
产品信息
概述| 货号 | 14163-10mg |
| 描述 | Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells.1 TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.1 It is effective in a variety of types of cancer, including aggressive brain cancers.1,2,3 |
| 别名 | CCRG 81045;MB 39831;Methazolastone;NSC 362856;Temodal;Temodar®;TMZ; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Marchesi, F.,Turriziani, M.,Tortorelli, G., et al. Triazene compounds: Mechanism of action and related DNA repair systems. Pharmacol. Res. 56(4), 275-287 (2007).
2.Khan, O.A.,Ranson, M.,Michael, M., et al. A phase II trial of lomeguatrib and temozolomide in metastatic colorectal cancer. Br. J. Cancer 98(10), 1614-1618 (2008).
3.Daniel, R.A.,Rozanska, A.L.,Mulligan, E.A., et al. Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699. Br. J. Cancer 103(10), 1588-1596 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 194.2 |
| 分子式 | C6H6N6O2 |
| CAS号 | 85622-93-1 |
| 稳定性 | ≥ 2 years |
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