Daunorubicin (hydrochloride)
货号：
14159-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 14159-5mg |
| 描述 | Daunorubicin is an antitumor antibiotic widely used in the treatment of acute myeloid leukemias (AMLs). At 0.2-1μM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 AML cells.1 However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations.1 In mature AML cells, daunorubicin has been shown to trigger a ROS-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.2,1 |
| 别名 | NDC 0082-4155;Ondena;RP 13057; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Laurent, G. and Jaffrézou, J.P. Signaling pathways activated by daunorubicin. Blood 98(4), 913-924 (2001).
2.Bose, R.,Verheij, M.,Haimovitz-Friedman, A., et al. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 82, 405-414 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 564 |
| 分子式 | C27H29NO10 • HCl |
| CAS号 | 23541-50-6 |
| 稳定性 | ≥ 2 years |
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