| 货号 | 13829-500ug |
| 描述 | Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine (Item No. 13603) and S-adenosylmethionine (Item No. 13956) that was originally isolated from Streptomyces.1,2 While it has limited use as an antibiotic due to its high in vivo toxicity, sinefungin has proved useful as a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 μM).3,4,5,6,7 |
| 别名 | A 9145;Antibiotic A 9145;Antibiotic 32232RP;RP 32232; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nolan, L.L. Molecular target of the antileishmanial action of sinefungin. Antimicrobial Agents and Chemotherapy 31(10), 1542-1548 (1987). 2.Maguire, M.P.,Feldman, P.L. and Rapoport, H. Stereoselective synthesis and absolute stereochemistry of sinefungin. The Journal of Organic Chemistry 55(3), 948-955 (1990). 3.Cole, P.A. Chemical probes for histone-modifying enzymes. Nature Chemical Biology 4(10), 590-597 (2008). 4.Bissinger, E.M.,Heinke, R.,Sippl, W., et al. Targeting epigenetic modifiers: Inhibitors of histone methyltransferases. Med.Chem.Commun. (2010). 5.Horiuchi, K.Y.,Eason, M.M.,Ferry, J.J., et al. Assay development for histone methyltransferases. Assay and Drug Development Technologies 11(4), 227-236 (2013). 6.Copeland, R.A.,Solomon, M.E. and Richon, V.M. Protein methyltransferases as a target class for drug discovery. Nature Reviews.Drug Discovery 8, 724-732 (2009). 7.Schluckebier, G.,Kozak, M.,Bleimling, N., et al. Differential binding of S-adenosylmethionine S-adenosylhomocysteine and sinefungin to the adenine-specific DNA methyltransferase M. TaqI. Journal of Molecular Biology 265, 56-67 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 2-8 |
| 纯度 | ≥95% |
| 计算分子量 | 381.4 |
| 分子式 | C15H23N7O5 |
| CAS号 | 58944-73-3 |
| 稳定性 | ≥ 1 year |
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