KN-62
货号：
13318-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 13318-1mg |
| 描述 | KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII; IC50 = 900 nM).1 It does not affect the activity of several other kinases when tested at 10 µM.2 KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tokunitsu, H.,Chijiwa, T.,Hagiwara, M., et al. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific Inhibitor of Ca2+/calmodulin-dependent protein kinase II. The Journal of Biological Chemisty 265(8), 4315-4320 (1990).
2.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000).
3.Chessell, I.P.,Michel, A.D. and Humphrey, P.P.A. Effects of antagonists at the human recombinant P2X7 receptor. British Journal of Pharmacology 124, 1314-1320 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 721.9 |
| 分子式 | C38H35N5O6S2 |
| CAS号 | 127191-97-3 |
| 稳定性 | ≥ 2 years |
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