VER-50589
货号：
13132-500ug 基本售价：
546.0 元 规格：
500 ug
产品信息
概述| 货号 | 13132-500ug |
| 描述 | The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-50589 is an isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM.1 It produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel.1 Consistent with inhibition of Hsp90, VER-50589 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.1 VER-50589 shows favorable pharmacokinetics and impairs tumor growth in animals.1 Importantly, glioblastoma cells do not acquire resistance to VER-50589 and resistance to other Hsp90 inhibitors does not produce cross-resistance to VER-50589.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sharp, S.Y.,Prodromou, C.,Boxall, K., et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Molecular Cancer Therapeutics 6(4), 1198-1211 (2007).
2.Gaspar, N.,Sharp, S.Y.,Pacey, S., et al. Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells. Cancer Research 69(5), 1966-1975 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 388.8 |
| 分子式 | C19H17ClN2O5 |
| CAS号 | 747413-08-7 |
| 稳定性 | ≥ 2 years |
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