6-Shogaol
货号：
11901-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 11901-1mg |
| 描述 | 6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.1 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.2 It can also activate both TRPV1 and TRPA1 channels (EC50s = 0.32 and 16 µM, respectively).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ling, H.,Yang, H.,Tan, S.H., et al. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Brit.J.Pharmacol. 161, 1763-1777 (2010).
2.Bak, M.J.,Ok, S.,Jun, M., et al. 6-Shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. Molecules 17, 8037-8055 (2012).
3.Morera, E.,De Petrocellis, L.,Morera, L., et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorganic & Medicinal Chemistry Letters 22(4), 1674-1677 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 276.4 |
| 分子式 | C17H24O3 |
| CAS号 | 555-66-8 |
| 稳定性 | ≥ 2 years |
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