| 货号 | 11885-500mg |
| 描述 | Acarbose is the first identified α-glucosidase inhibitor. It has been shown to delay the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase and sucrase with IC50 values of 0.16 and 2.9 µM, respectively.1,2 It has also been shown to bind to phosphorylase kinase, potentiating its activity.3 In clinical trials, acarbose has been used to inhibit postprandial hyperglycemia associated with diabetes without cardiovascular complications.4 |
| 别名 | BAY-g 5421; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Natori, Y.,Imahori, T.,Murakami, K., et al. The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(2), 738-741 (2011). 2.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008). 3.Nadeau, O.W.,Liu, W.,Boulatnikov, I.G., et al. The glucoamylase inhibitor acarbose is a direct activator of phosphorylase kinase. Biochem. 49(31), 6505-6507 (2010). 4.Standl, E., and Schnell, O. Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. Diab.Vasc.Dis.Res. 9(3), 163-169 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 645.6 |
| 分子式 | C25H43NO18 |
| CAS号 | 56180-94-0 |
| 稳定性 | ≥ 2 years |
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