| 货号 | 11882-100mg |
| 描述 | Sofalcone is an anti-ulcer chalcone derivative.1,2 It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM.3 Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.4,5,6 |
| 别名 | Solon;SU 88; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kimura, M.,Saziki, R.,Arai, I., et al. Effect of 2-carboxymethoxy-4, 4-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in rats. Japan.J.Pharmacol. 35, 389-396 (1984). 2.Suwa, T.,Nakazima, M.,Shinozaki, A., et al. Cytoprotective effect of SU-88, an anti-ulcer agent, in the rat. Japan.J.Pharmacol. 35, 47-53 (1984). 3.Tanaka, H.,Nakamura, S.,Onda, K., et al. Sofalcone, an anti-ulcer chalcone derivative, suppresses inflammatory crosstalk between macrophages and adipocytes and adipocyte differentiation: Implication of heme-oxygenase-1 induction. Biochemical and Biophysical Research Communications 381(4), 566-571 (2009). 4.Isomoto, H.,Furusu, H.,Ohnita, K., et al. Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin. World Journal of Gastroenterology 11(11), 1629-1633 (2005). 5.Higuchi, K.,Watanabe, T.,Tanigawa, T., et al. Sofalcone, a gastroprotective drug, promotes gastric ulcer healing following eradication therapy for Heliobacter pylori: A randomized controlled comparative trial with cimetidine, an H2-receptor antagonist. Journal of Gastroenterology and Hepatology 25, S155-S160 (2010). 6.Shibuya, A.,Onda, K.,Kawahara, H., et al. Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells. Biochemical and Biophysical Research Communications 398(3), 581-584 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 450.5 |
| 分子式 | C27H30O6 |
| CAS号 | 64506-49-6 |
| 稳定性 | ≥ 2 years |
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