| 货号 | 11816-100mg |
| 描述 | Artemisinin is a natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium(IC50 = 4.0 nM).1,2 It is usually used in combination therapy for the treatment of malaria.3 Artemisinin is also used against a wide range of trematodes, including Schistosoma.3,4 Sesquiterpene lactones like artemisinin, artemether (Item No. 11815), and artesunate (Item No. 11817) have potential applications in certain types of cancer and inflammatory conditions.5 |
| 别名 | NSC 369397; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pandey, A.V.,Tekwani, B.L.,Singh, R.L., et al. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. The Journal of Biological Chemisty 274, 19383-19388 (1999). 2.Akoachere, M.,Buchholz, K.,Fischer, E., et al. In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrobial Agents and Chemotherapy 49(11), 4592-4597 (2005). 3.Meshnick, S.R.,Taylor, T.E., and Kamchonwongpaisan, S. Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy. Microbiological Reviews 60, 301-315 (1996). 4.Liu, R.,Dong, H.F.,Guo, Y., et al. Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: A systematic review and meta-analysis. Parasit.Vectors 4, 1-17 (2011). 5.Ghantous, A.,Gali-Muhtasib, H.,Saliba, N.A., et al. What made sesquiterpene lactones reach cancer clinical trials? Drug Discovery Today 15(15-16), 668-678 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 282.3 |
| 分子式 | C15H22O5 |
| CAS号 | 63968-64-9 |
| 稳定性 | ≥ 2 years |
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