6-Gingerol
货号：
11707-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 11707-1mg |
| 描述 | 6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM).1 6-Gingerol also non-competitively inhibits serotonin currents (IC50 = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC50s = 129 and 125 µM).2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Morera, E.,De Petrocellis, L.,Morera, L., et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorganic & Medicinal Chemistry Letters 22(4), 1674-1677 (2012).
2.Jin, Z.,Lee, G.,Kim, S., et al. Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J.Physiol.Pharmacol. 18(2), 149-153 (2014).
3.Nishio, K.,Fukuhara, A.,Omata, Y., et al. Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Bioorganic & Medicinal Chemistry 16(24), 10332-10337 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 294.4 |
| 分子式 | C17H26O4 |
| CAS号 | 23513-14-6 |
| 稳定性 | ≥ 1 year |
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