5-Fluorocytosine
货号：
11635-500mg 基本售价：
546.0 元 规格：
500 mg
产品信息
概述| 货号 | 11635-500mg |
| 描述 | 5-Fluorocytosine (5-FC), a fluorinated pyrimidine analog, is a synthetic antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil.1 5-fluorouracil, a widely used cytotoxic drug, is further metabolized to fluorinated ribo- and deoxyribonucleotides, resulting in the inhibition of DNA and protein synthesis, which has multiple effects including inhibition of Candida species and C. neoformans infections and cytotoxicity towards cancer cells.1,2 In combination with a retroviral replicating vector carrying a cytosine deaminase prodrug-activating gene, 5-FC has been shown to selectively eliminate CT26 and Tu-2449 tumor cells in vitro(IC50s = 4.2 and 1.5 μM, respectively) and to significantly improve survival and reduce tumor size (at a dose of 500 mg/kg) in two different syngeneic mouse glioma models.3 |
| 别名 | Ancobon;Ancotil;5-FC;NSC 103805;Ro 2-9915; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Herbrecht, R.,Nivoix, Y.,Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005).
2.Fuerer, C., and Iggo, R. 5-Fluorocytosine increases the toxicity of Wnt-targeting replicating adenoviruses that express cytosine deaminase as a late gene. Gene Ther. 11, 142-151 (2004).
3.Ostertag, D.,Amundson, K.K.,Lopez Espinoza, F., et al. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. Neuro Oncol. 14(2), 145-159 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 129.1 |
| 分子式 | C4H4FN3O |
| CAS号 | 2022-85-7 |
| 稳定性 | ≥ 2 years |
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