| 货号 | 11497-5mg |
| 描述 | Saracatinib is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively).1 It less effectively inhibits other receptor and non-receptor tyrosine kinases as well as assorted serine/threonine kinases.1,2,3 Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival.1,2,4 Through its effects on c-Src, it reduces osteoclast bone resorption.2 Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.5 |
| 别名 | AZD 0530; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hennequin, L.F.,Allen, J.,Breed, J., et al. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. Journal of Medicinal Chemistry 49(22), 6465-6488 (2006). 2.Allen, J.G.,Fotsch, C., and Babij, P. Emerging targets in osteoporosis disease modification. Journal of Medicinal Chemistry 53(11), 4332-4353 (2010). 3.Lee, K.,Kim, J.,Jeong, K.W., et al. Structure-based virtual screening of Src kinase inhibitors. Bioorganic & Medicinal Chemistry 17(8), 3152-3161 (2009). 4.Saad, F., and Lipton, A. SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancer. Cancer Treatment Reviews 36(2), 177-184 (2010). 5.de Wispelaere, M.,LaCroix, A.J., and Yang, P.L. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via fyn kinase. Journal of Virology 87(13), 7367-7381 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 542 |
| 分子式 | C27H32ClN5O5 |
| CAS号 | 379231-04-6 |
| 稳定性 | ≥ 2 years |
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