| 货号 | 11313-5mg |
| 描述 | Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both α- and β-glucosidases, inhibiting lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively, and lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively.1 It is effective both in vitroandin vivo.2,3 Through its effects on glucosidases, castanospermine blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions that are dependent on glycosylation, including angiogenesis.3,4 Castanospermine also interferes with viral replication and infection that is dependent on glucosidase activity.5,6,7 |
| 别名 | 6,7-Diepicastanospermine;6-Epicastanospermine;1,6,7,8-Tetrahydroxyoctahydroindolizine;NSC 625381; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Winchester, B.G.,di Bello, I.C.,Richardson, A.C., et al. The structural basis of the inhibition of human glycosidases by castanospermine analogues. Biochemistry Journal 269, 227-231 (1990). 2.Saul, R.,Ghidoni, J.J.,Molyneux, R.J., et al. Castanospermine inhibits α-glucosidase activities and alters glycogen distribution in animals. Proceedings of the National Academy of Sciences of the United States of America 82, 93-97 (1985). 3.Pili, R.,Chang, J.,Partis, R.A., et al. The α-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth. Cancer Research 55, 2920-2926 (1995). 4.Simsolo, R.B.,Ong, J.M., and Kern, P.A. Characterization of lipoprotein lipase activity, secretion, and degredation at different sites of post-translational processing in primary cultures of rat adipocytes. Journal of Lipid Research 33, 1777-1784 (1992). 5.Montefiori, D.C.,Robinson, W.E., Jr., and Mitchell, W.M. Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America 85, 9248-9252 (1988). 6.Walker, B.D.,Kowalski, M.,Goh, W.C., et al. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proceedings of the National Academy of Sciences of the United States of America 84, 8120-8124 (1987). 7.Whitby, K.,Pierson, T.C.,Geiss, B., et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. Journal of Virology 79(14), 8698-8706 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 189.2 |
| 分子式 | C8H15NO4 |
| CAS号 | 79831-76-8 |
| 稳定性 | ≥ 2 years |
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