Ascomycin
货号：
11309-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 11309-5mg |
| 描述 | Ascomycin, produced by the fermentation of S. hygroscopicussubsp.ascomyceticus, is an ethyl analog of tacrolimus (FK-506) with potent immunosuppressant properties that prevents T-cell proliferation through initial binding to FK-506-binding protein 12 (FKBP12), an immunophilin that acts as the principal mediator of FK506- and rapamycin-induced immunosuppression.1,2 Ascomycin inhibits the enzymatic peptidyl-prolyl cis-trans isomerase and chaperone activities of PfFKBP35, an FKBP from P. falciparum, a causative agent of malaria in humans with an IC50 value of 0.52 μM.3 |
| 别名 | Changchuanmycin;FK-520;FR900520;Immunomycin;L 683590; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mrowietz, U. Macrolide immunosuppressants. Eur.J.Dermatol. 9(5), 346-351 (1999).
2.Andexer, J.N.,Kendrew, S.G.,Nur-e-Alam, M., et al. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proceedings of the National Academy of Sciences of the United States of America 108(12), 4776-4781 (2011).
3.Monaghan, P.,Fardis, M.,Revill, W.P., et al. Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds. Journal of Infectious Diseases 191, 1342-1349 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 792 |
| 分子式 | C43H69NO12 |
| CAS号 | 104987-12-4 |
| 稳定性 | ≥ 2 years |
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