| 货号 | 11095-50mg |
| 描述 | DL-Palmitoylcarnitine (chloride) is a long-chain acylcarnitine with both intracellular and extracellular roles. Within the cell, palmitoylcarnitine is transported into mitochondria to deliver palmitate for fatty acid oxidation and energy production.1 Exogenously added DL-palmitoylcarnitine alters calcium mobilization in many cell types.2,3,4 It also affects endothelial and epithelial tight junctions, reducing resistance and increasing permeability while decreasing cell viability.5,6 |
| 别名 | NSC 628323;Palmitoyl-DL-carnitine chloride; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bezaire, V.,Bruce, C.R.,Heigenhauser, G.J.F., et al. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: Essential role in fatty acid oxidation. American Journal of Physiology.Endocrinology and Metabolism 290(3), E509-E515 (2006). 2.El-Hayek, R.,Valdivia, C.,Valdivia, H.H., et al. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophysical Journal 65(2), 779-789 (1993). 3.Stapleton, S.R.,Currie, K.P.M.,Scott, R.H., et al. Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. British Journal of Pharmacology 107, 1192-1197 (1992). 4.Muraki, K., and Imaizumi, Y. A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. Journal of Pharmacological Sciences 92, 252-258 (2003). 5.Duizer, E.,van der Wulp, C.,Versantvoort, C.H.M., et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. Journal of Pharmacology and Experimental Therapeutics 287(1), 395-402 (1998). 6.Ma, L.,Kuang, K.,Smith, R.W., et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. Experimental Eye Research 84(4), 790-798 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 436.1 |
| 分子式 | C23H46ClNO4 |
| CAS号 | 6865-14-1 |
| 稳定性 | ≥ 2 years |
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