ITF 2357
货号：
11045-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 11045-1mg |
| 描述 | ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFα, IL-1α, and IL-1β (IC50s = 10-22 nM).1 ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F(IC50s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Leoni, F.,Fossati, G.,Lewis, E.C., et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Molecular Medicine 11(1-12), 1-15 (2005).
2.Guerini, V.,Barbui, V.,Spinelli, O., et al. The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2V617F. Leukemia 22, 740-747 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 476 |
| 分子式 | C24H27N3O4 • HCl [H2O] |
| CAS号 | 732302-99-7 |
| 稳定性 | ≥ 2 years |
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