H-89 (hydrochloride)
货号：
10010556-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 10010556-5mg |
| 描述 | Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. H-89 is a potent, cell permeable inhibitor of PKA that demonstrates an IC50 value of 0.14 µM and a Ki value of 48 nM in standard kinase assays.1,2 While widely used to disrupt PKA signaling, the inhibitory activity of H-89 is non-selective. H-89 also inhibits S6K1, MSK1, ROCK-II, PKBα, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively.1 |
| 别名 | 5-Isoquinolinesulfonamide;Protein Kinase Inhibitor H-89; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000).
2.Engh, R.A.,Girod, A.,Kinzel, V., et al. Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89 structural implications for selectivity. The Journal of Biological Chemisty 271(42), 26157-26164 (1996).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 519.3 |
| 分子式 | C20H20BrN3O2S • 2HCl |
| CAS号 | 130964-39-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
