| 货号 | 10010266-5mg |
| 描述 | The transcription factor NF-κB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules.1 In the cytoplasm, inactive NF-κB complexes are bound to an inhibitor IκB.2 However in response to certain stimuli, IκB is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-κB to the nucleus.3 BAY 11-7082 selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation.4 This compound inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866 (1999). 2.Gilmore, T.D. The Rel/NF-κB signal transduction pathway: Introduction. Oncogene 18, 6842-6844 (1999). 3.Karin, M. The beginning of the end: IκB kinase (IKK) and NF-κB activation. The Journal of Biological Chemisty 274(39), 27339-27342 (1999). 4.Pierce, J.W.,Schoenleber, R.,Jesmok, G., et al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. The Journal of Biological Chemisty 272(34), 21096-21103 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 207.3 |
| 分子式 | C10H9NO2S |
| CAS号 | 19542-67-7 |
| 稳定性 | ≥ 2 years |
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