| 货号 | 10009570-1mg |
| 描述 | Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways.1 SecinH3 is a selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50 values of 2.4 to 5.6 µM.2 It binds the Sec7 domain of these small Arf-GEFs but does not bind Sec7 domains of larger Arf-GEFs.3 In human liver carcinoma HepG2 cells, SecinH3 prevents cytohesin-dependent insulin signaling.2 In mice, SecinH3 produces hepatic insulin resistance.2 Inhibition of the cytohesin GEF from Drosophila, Steppke, blocks insulin signaling and interferes with development.4 SecinH3 is useful for studying the diverse roles of cytohesins, including the regulation of receptor-mediated cancer cell proliferation.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kolanus, W. Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction. Immunological Reviews 218, 102-113 (2007). 2.Hafner, M.,Schmitz, A.,Grüne, I., et al. Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance. Nature 444, 941-944 (2006). 3.Bi, X.,Schmitz, A.,Hayallah, A.M., et al. Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe. Angewandte Chemistry International Edition English 47(49), 9565-9568 (2008). 4.Fuss, B.,Becker, T.,Zinke, I., et al. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444(7121), 945-948 (2006). 5.Pan, T.,Sun, J.,Hu, J., et al. Cytohesins/ARNO: The function in colorectal cancer cells. PLoS One 9(3), e90997 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 460.5 |
| 分子式 | C24H20N4O4S |
| CAS号 | 853625-60-2 |
| 稳定性 | ≥ 2 years |
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