CAY10443
货号：
10004177-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 10004177-5mg |
| 描述 | Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.1 Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 µM.2 These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs. |
| 别名 | (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cecconi, F.,Alvarez-Bolado, G.,Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737 (1998).
2.Nguyen, J.T., and Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proceedings of the National Academy of Sciences of the United States of America 100(13), 7533-7538 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 336.1 |
| 分子式 | C17H15Cl2NO2 |
| CAS号 | 582314-48-5 |
| 稳定性 | ≥ 1 year |
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