Ellipticine
货号：
18742-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 18742-5mg |
| 描述 | Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II.1,2,3 It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues.2,3 Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7 µM.2 |
| 别名 | NSC 71795; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kohn, K.W.,Waring, M.J.,Glaubiger, D., et al. Intercalative binding of ellipticine to DNA. Cancer Research 35(1), 71-76 (1975).
2.Stiborová, M.,Poljakova, J.,Martinkova, E., et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip.Toxicol. 4(2), 98-105 (2011).
3.Aimová, D.,Svobodová, L.,Kotrbová, V., et al. The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism. Drug Metabolism and Disposition 35(10), 1926-1934 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 246.3 |
| 分子式 | C17H14N2 |
| CAS号 | 519-23-3 |
| 稳定性 | ≥ 2 years |
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