PU-WS13
货号：
18409-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 18409-1mg |
| 描述 | Glucose-regulated protein 94 (Grp94) is a stress-inducible molecular chaperone belonging to the heat shock protein (Hsp) family and, as a result, is also known as Hsp90B1.1 Grp94 is essential for the processing of proteins that have been implicated in tumorigenesis, including insulin-like growth factor 1 (IGF-1), Toll-like receptors (TLRs), and integrins.1 It also functions in antigen presentation, and its secreted form can elicit innate and adaptive immune responses.1 PU-WS13 is a cell-permeable inhibitor of Grp94 (EC50 = 220 nM).2 It displays selectivity for Grp94 over the related Hsps Trap-1, Hsp90α, and Hsp90β. PU-WS13 blocks the proliferation of HER2 over-expressing SK-BR-3 cells in the sub-G1 phase and induces apoptosis, but doesn’t significantly affect the survival of normal cells.2 It induces both apoptosis and necrosis in multiple myeloma cells but does not induce death in pre-B leukemic cells.3 Unlike pan-Hsp90 inhibitors, PU-WS13 does not activate a feedback heat-shock response.2 |
| 别名 | WS13; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, A.S. Glucose-regulated proteins in cancer: Molecular mechanisms and therapeutic potential. Nature Reviews.Cancer 14(4), 263-276 (2014).
2.Patel, P.D.,Yan, P.,Seidler, P.M., et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature Chemical Biology 9(11), 677-684 (2013).
3.Hua, Y.,White-Gilbertson, S.,Kellner, J., et al. Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clinical Cancer Research 19(22), 6242-6251 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 411.4 |
| 分子式 | C17H20Cl2N6S |
| CAS号 | 1454619-14-7 |
| 稳定性 | ≥ 2 years |
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