| 货号 | 11797-500ug |
| 描述 | Withanolide A is a natural product isolated from the medicinal plant W. somnifera that has antioxidant and neuroprotective activity.1 It helps to promote neurite outgrowth at 1 µM in cultured neurons and in rodents injected with Aβ(25-35), and also recovers Aβ(25-35)-induced memory deficit in mice (10 µmol/kg/day).2,3 Withanolide A reverses hypoxia-mediated neurodegeneration by restoring hypoxia-induced glutathione depletion in the hippocampus of mice.4 |
| 别名 | Withaniol;WL-A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kurapati, K.R.V.,Samikkannu, T.,Atluri, V.S.R., et al. β-Amyloid1-42, HIV-1Bα-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS One 9(11), 1-23 (2014). 2.Zhao, J.,Nakamura, N.,Hattori, M., et al. Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem.Pharm.Bull.(Tokyo) 50(6), 760-765 (2002). 3.Kuboyama, T.,Tohda, C., and Komatsu, K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. British Journal of Pharmacology 144(7), 961-971 (2005). 4.Baitharu, I.,Jain, V.,Deep, S.N., et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One 9(10), 1-17 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 470.6 |
| 分子式 | C28H38O6 |
| CAS号 | 32911-62-9 |
| 稳定性 | ≥ 2 years |
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