O-11
货号：
90510-1mg 基本售价：
532.0 元 规格：
1 mg
产品信息
概述| 货号 | 90510-1mg |
| 描述 | O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 µM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 |
| 别名 | 11-Oxatetradecanoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Doering, T.L.,Raper, J.,Buxbaum, L.U., et al. An analog of myristic acid with selective toxicity for African trypanosomes. Science 252, 1851-1854 (1991).
2.Doering, T.L.,Lu, T.,Werbovetz, K.A., et al. Toxicity of myristic acid analogs toward African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America 91, 9735-9739 (1994).
3.Langner, C.A.,Lodge, J.K.,Travis, S.J., et al. 4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I. The Journal of Biological Chemisty 267(24), 17159-17169 (1992).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 230.3 |
| 分子式 | C13H26O3 |
| CAS号 | 119290-12-9 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
