| 货号 | 16355-10mg |
| 描述 | Gaboxadol is a GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)).1 It also acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).1 Gaboxadol has been studied as a non-opioid analgesic and a novel hypnotic agent.2,3,4 |
| 别名 | THIP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Johnston, G.A.R.,Chebib, M.,Hanrahan, J.R., et al. Neurochemicals for the investigation of GABAC receptors. Neurochemical Research 35(12), 1970-1977 (2010). 2.Drasbek, K.R. and Jensen, K. THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex. Cerebral Cortex 16(8), 1134-1141 (2006). 3.Vashchinkina, E.,Panhelainen, A.,Vekovischeva, O.Y., et al. GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons. Journal of Neuroscience 32(15), 5310-5320 (2012). 4.Deacon, S.,Staner, L.,Staner, C., et al. Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia. Sleep 30(3), 281-287 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 176.6 |
| 分子式 | C6H8N2O2 • HCl |
| CAS号 | 85118-33-8 |
| 稳定性 | ≥ 2 years |
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