| 货号 | 15316-25mg |
| 描述 | Auranofin is a gold-thiol complex with anti-inflammatory and immunosuppressive actions.1,2 It potently inhibits thioredoxin reductase (IC50 = 0.2 μM), preventing reduction of thioredoxin and altering oxidative signaling relevant to DNA synthesis, transcription, apoptosis, and disease.2,3 Auranofin blocks LPS-mediated expression of inflammatory mediators in RAW 264.7 macrophages at 10-20 μM and blocks NF-κB signaling in a stimulus- and cell type-dependent manner.2,4 Through these actions, this compound has applications in rheumatoid arthritis and other diseases with an inflammatory component, including cancer.1,2 Auranofin also has potential value against certain bacteria, viruses, and parasites.1,2 |
| 别名 | NSC 321521;Ridauragold thiol;SKF 39162; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kean, W.F.,Hart, L. and Buchanan, W.W. Disease-modifying drugs. Auranofin. Brit.J.Rheumatol. 36, 560-572 (1997). 2.Madeira, J.M.,Gibson, D.L.,Kean, W.F., et al. The biological activity of auranofin: Implications for novel treatment of diseases. Inflammopharmacology 20(6), 297-306 (2012). 3.Cox, A.G.,Brown, K.K.,Arner, E.S.J., et al. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochemical Pharmacology 76(9), 1097-1099 (2008). 4.Han, S.,Kim, K.,Kim, H., et al. Auranofin inhibits overproduction of pro-inflammatory cytokines, cyclooxygenase expression and PGE2 production in macrophages. Archives of Pharmacal Research 31(1), 67-74 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 678.5 |
| 分子式 | C20H34AuO9PS |
| CAS号 | 34031-32-8 |
| 稳定性 | ≥ 2 years |
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