CCG-203971
货号：
15075-5mg 基本售价：
532.0 元 规格：
5 mg
产品信息
概述| 货号 | 15075-5mg |
| 描述 | Signaling through small G proteins of the RhoA subfamily, including RhoC, induces actin-regulated cytosolic-to-nuclear translocation of the oncogene product megakaryoblastic leukemia 1 (MKL1), which binds to serum response factor (SRF).1 The MKL1/SRF complex, in turn, activates the transcription of serum response element (SRE) regulated genes, stimulating cell migration, a process that is central to metastasis.1 CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.2 This compound also inhibits PC-3 cell migration (IC50 = 4.2 μM), as determined by a scratch wound assay.2 CCG-203971 causes no cytotoxicity when evaluated by WST-1 assay.2 It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Evelyn, C.R.,Wade, S.M.,Wang, Q., et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Molecular Cancer Therapeutics 6(8), 2249-2260 (2007).
2.Bell, J.L.,Haak, A.J.,Wade, S.M., et al. Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents. Bioorganic & Medicinal Chemistry Letters 23(13), 3826-3832 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 408.9 |
| 分子式 | C23H21ClN2O3 |
| CAS号 | 1443437-74-8 |
| 稳定性 | ≥ 2 years |
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