PF-8380
货号：
12018-1mg 基本售价：
532.0 元 规格：
1 mg
产品信息
概述| 货号 | 12018-1mg |
| 描述 | Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion.1 PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an in vitro enzyme assay).1 PF-8380 (30 mg/kg) reduces LPA production by >95% following carrageenan-induced inflammation in rats and inhibits autotaxin activity in human whole blood (IC50 = 101 nM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gierse, J.,Thorarensen, A.,Beltey, K., et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. Journal of Pharmacology and Experimental Therapeutics 334(1), 310-317 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 478.3 |
| 分子式 | C22H21Cl2N3O5 |
| CAS号 | 1144035-53-9 |
| 稳定性 | ≥ 2 years |
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