| 货号 | 11434-1mg |
| 描述 | Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression.1,2 Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models.3,4,5 |
| 别名 | A 2371;Antibiotic LA 7017;Aureolic Acid;NSC 24559;PA 144;Plicamycin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sleiman, S.F.,Berlin, J.,Basso, M., et al. Histone deacetylase inhibitors and mithramycin A impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration. Pharmaceuticals 4, 1183-1195 (2011). 2.Sleiman, S.F.,Langley, B.C.,Basso, M., et al. Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. Journal of Neuroscience 31(18), 6858-6870 (2011). 3.Lee, T.J.,Jung, E.M.,Lee, J.T., et al. Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites. Molecular Cancer Therapeutics 5, 2737-2746 (2006). 4.Jia, Z.,Gao, Y.,Wang, L., et al. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Research 70, 1111-1119 (2010). 5.Duverger, V.,Murphy, A.M.,Sheehan, D., et al. The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF). British Journal of Cancer 90, 2025-2031 (2004). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1085 |
| 分子式 | C52H76O24 |
| CAS号 | 18378-89-7 |
| 稳定性 | ≥ 2 years |
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