| 货号 | 10010518-5mg |
| 描述 | PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1.1 It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits 2,1 and reduces oxidant stress-induced apoptosis in endothelial cells.3 PD 146176 inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.4 In addition, it lacks significant non-specific antioxidant properties.2 |
| 别名 | NSC 168807; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bocan, T.M.A.,Rosebury, W.S.,Mueller, S.B., et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. Atherosclerosis 136, 203-216 (1998). 2.Sendobry, S.M.,Cornicelli, J.A.,Welch, K., et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. British Journal of Pharmacology 120, 1199-1206 (1997). 3.Sordillo, L.M.,Weaver, J.A.,Cao, Y.Z., et al. Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells. Prostaglandins & Other Lipid Mediators 76, 19-34 (2005). 4.Succol, F., and Praticò, D. A role for 12/15 lipoxygenase in the amyloid ß precursor protein metabolism. Journal of Neurochemistry 103, 380-387 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 237.3 |
| 分子式 | C15H11NS |
| CAS号 | 4079-26-9 |
| 稳定性 | ≥ 2 years |
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