N-Arachidonoyl-L-Serine-d8
货号：
10007428-100ug 基本售价：
532.0 元 规格：
100 ug
产品信息
概述| 货号 | 10007428-100ug |
| 描述 | N-Arachidonoyl-L-serine-d8(ARA-S-d8) contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of ARA-S (Item No. 10005455) by GC- or LC-mass spectrometry. Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.1 ARA-S is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to CB1 and CB2 receptors or vanilloid receptor 1. Like cannabidiol (Item No. 90080), ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD, CAY10429 Item No. 10004259) in an anesthetized rat blood pressure model.2 However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta, as well as increases phosphorylation of Akt and MAPK in HUVEC.3 The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation. |
| 别名 | ARA-S-d8; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bisogno, T.,Melck, D.,Bobrov, M.Y., et al. N-acyl-dopamines: Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochemistry Journal 351, 817-824 (2001).
2.Milman, G.,Maor, Y.,Horowitz, M., et al. Arachidonoyl-serine, an endocannabinoid-like bioactive constituent of rat brain. 14th Annual Symposium on the Cannabinoids 133-133 (2004).
3.Milman, G.,Maor, Y.,Abu-Lafi, S., et al. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proceedings of the National Academy of Sciences of the United States of America 103(7), 2428-2433 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d8) |
| 计算分子量 | 399.6 |
| 分子式 | C23H29D8NO4 |
| 稳定性 | ≥ 1 year |
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