| 货号 | 13182-1mg |
| 描述 | SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC50s = 0.02, 0.03, and 0.51 µM, respectively).1 It is much less effective against other receptor tyrosine kinases.1 SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sun, L.,Tran, N.,Liang, C., et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 42(25), 5120-5130 (1999). 2.Heryanto, B.,Lipson, K.E., and Rogers, P.A.W. Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouse. Reproduction 125, 337-346 (2003). 3.Ying, Q.L.,Wray, J.,Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519-524 (2008). 4.Hasse, C.,Holz, O.,Lange, E., et al. FGFR-ERK signaling is an essential component of tissue separation. Dev.Biol. 395(1), 154-166 (2014). 5.Kachel, P.,Trojanowicz, B.,Sekulla, C., et al. Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. BMC Cancer 15:140, (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 296.3 |
| 分子式 | C17H16N2O3 |
| CAS号 | 215543-92-3 |
| 稳定性 | ≥ 2 years |
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