| 货号 | 16915-1mg |
| 描述 | The high affinity nerve growth factor (NGF) receptor, also known as NGF tyrosine kinase receptor A (TrkA), is involved in the development and maturation of the nervous system. Aberrant expression is associated with certain forms of cancer and congenital insensitivity to pain with anhidrosis.1,2 GW 441756 is a potent inhibitor of TrkA (IC50 = 2 nM).3 It displays >100-fold selectivity over a panel of related kinases.3 GW 441756 has been used to clarify the role of TrkA in regulating gene expression in neuroblastoma cells and, more recently, in amyloid-β protein precursor cleavage in neuroglioma cells.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fujimoto, M.,Kitazawa, R.,Maeda, S., et al. Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression. Oncogene 24(32), 5108-5118 (2005). 2.Mardy, S.,Miura, Y.,Endo, F., et al. Congenital insensitivity to pain with anhidrosis: Novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. American Journal of Human Genetics 64(6), 1570-1579 (1999). 3.Wood, E.R.,Kuyper, L.,Petrov, K.G., et al. Discovery and in vitro evaluation of potent TrkA kinase inhibitors: Oxindole and aza-oxindoles. Bioorganic & Medicinal Chemistry Letters 14, 953-957 (2004). 4.Jung, E.J.,Lee, S.Y. and Kim, C.W. Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells. Proteomics 13(2), 355-367 (2013). 5.Zhang, Q.,Descamps, O.,Hart, M.J., et al. Paradoxical effect of TrkA inhibition in Alzheimer’s disease models. J.Alzheimers Dis. 40(3), 605-617 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 275.3 |
| 分子式 | C17H13N3O |
| CAS号 | 504433-23-2 |
| 稳定性 | ≥ 2 years |
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