| 货号 | 15125-5mg |
| 描述 | Choline acetyltransferase (ChAT) mediates the synthesis of the neurotransmitter acetylcholine from acetyl-CoA and choline. In addition to its critical role in neurosignaling, deficiencies in ChAT are linked to congenital myasthenic syndromes, Alzheimer’s disease, and multiple sclerosis.1,2,3 α-NETA is a stable, non-competitive, and slowly reversible inhibitor of ChAT (IC50 = 9 μM).4,5 This naturally fluorescent compound is a poor inhibitor of cholinesterases and carnitine acetyltransferase.5 α-NETA is commonly used in cells in culture.6,7 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shen, X.M.,Crawford, T.O.,Brengman, J., et al. Functional consequences and structural interpretation of mutations of human choline acetyltransferase. Human Mutation 32(11), 1259-1267 (2011). 2.Mukaetova-Ladinska, E.B.,Andras, A.,Milne, J., et al. Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with lewy bodies. Journal of Neuropathology and Experimental Neurology 72(1), 53-60 (2013). 3.Vijayaraghavan, S.,Karami, A.,Aeinehband, S., et al. Regulated extracellular choline acetyltransferase activity - The plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathway. PLoS One 8(6), e65936 (2013). 4.Sastry, B.V.,Jaiswal, N.,Owens, L.K., et al. 2-(α-Naphthoyl)ethyltrimethylammonium iodide and its β-isomer: New selective, stable and fluorescent inhibitors of choline acetyltransferase. Journal of Pharmacology and Experimental Therapeutics 245(1), 72-80 (1988). 5.Sastry, B.V.,Jaiswal, N.,Janson, V., et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacological Research Communications 20(9), 751-771 (1988). 6.Eaton, B.M. and Sooranna, S.R. Regulation of the choline transport system in superfused microcarrier cultures of BeWo cells. Placenta 19(8), 663-669 (1998). 7.Sawatzky, D.A.,Kingham, P.J.,Durcan, N., et al. Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells. American Journal of Physiology.Lung Cellular and Molecular Physiology 285(6), L1296-L1304 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 369.2 |
| 分子式 | C16H20NO • I |
| CAS号 | 31059-54-8 |
| 稳定性 | ≥ 2 years |
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